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NAME John Edward Heuser
BORN August 29, 1942; Pittsburgh, Pennsylvania, U.S.A.
PERSONAL Married, with three children born '80, '82 and '85, plus one stepchild
EDUCATION 1964, B.A., cum laude, Harvard College
1969, M.D., magna cum laude, Harvard Medical School
1970-1973, Graduate studies in Biophysics, University College London
PRESENT POSITION

Professor of Biophysics, Department of Cell Biology and Physiology
Washington University School of Medicine
660 South Euclid Avenue, St. Louis, Missouri 63110

EXPERIENCE
1963-1967 Undergraduate apprentice in J. David Robertson's Electron Microscopy Lab, Harvard Medical School and the McLean Hospital, Belmont, MA
1969-1974 USPHS Fellow and Moseley Travelling Fellow of Harvard University, as Postdoctoral trainee in the Biophysics Unit of University College, London, under Sir Bernard Katz and Ricardo Miledi
1970-1972 USPHS Military service in Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS, Bethesda, MD with Dr. Thomas S. Reese
1974-1980 Assistant, Associate, and then Full Professor of Physiology, Department of Physiology, University of California, San Francisco, CA
1980- Professor of Biophysics, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110
AWARDS

Borden Award for outstanding research in medical school, 1969

Moseley Travelling Fellowship of Harvard University 1972-73

First annual Bensley Memorial Lectureship, American Association of Anatomists, 1979

Alden Spencer Award, Columbia University, 1980

Alexander Forbes Memorial Lectureship, Grass Foundation, 1981

Keith R. Porter Memorial Lectureship, American Society for Cell Biology, 1985

Carl Zeiss Lectureship, European Society for Cell Biology, 1995

Kuffler Memorial Lectureship, Stanford University, 1999

Christiana Smith Lectureship, Mt.Hoyoke & Smith Colleges, 2001

A.R. Martin Lectureship, University of Colorado, 2004

Fellow, American American Academy of Arts and Sciences, 2005

Fellow, American Association for the Advancement of Science, 2007

PROFESSIONAL ACTIVITIES

Associate Editor of the Journal of Cell Biology (past)

Associate Editor of the Journal of Neurocytology (curr)

Service to editorial boards of: Journal of Neurophysiology, Brain Research, Journal of Comparative Neurology, Journal of Neuroscience Methods, Gastroenterology, Cell, Anatomical Record, Journal of Molecular Biology, etc.

Ad Hoc reviewer for NINCDS, NCRR, and National Science Foundation

TEACHING ACTIVITIES
1980-1990 Lecturer (with U.W. Goodenough) in Washington University Medical School courses in Cell Biology and Neurobiology
1980-1995 Lecturer in Washington University Medical School courses in Cell Biology and Neurobiology
1974-1980 Lecturer in UCSF graduate and medical school courses: Cell Biology and Neurobiology
1974-1995 Director of graduate course: Neuroanatomical Methods
1975-1998 Instructor, Summer Neurobiology course, Marine Biological Laboratory, Woods Hole, MA

 

CURRENT RESEARCH INTERESTS

1. Freeze-etch electron microscopy as applied to cell and molecular biology

2. The structural basis of neuronal synaptic transmission

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  1. Heuser, J. E. and C. F. Doggenweiler (1966). The fine structural organization of nerve fibers, sheaths, and glial cells in the prawn, Palaemonetes vulgaris. J Cell Biol 30: 381-403.
  2. Doggenweiler, C. F. and J. E. Heuser (1967). Ultrastructure of the prawn nerve sheaths. Role of fixative and osmotic pressure in vesiculation of thin cytoplasmic laminae. J Cell Biol 34: 407-20.
  3. Heuser, J. and R. Miledi (1970). Autoradiography of labelled amino acids injected iontophoretically into the giant squid synapse. J Physiol 208: 55P-57P.
  4. Heuser, J., B. Katz and R. Miledi (1971). Structural and functional changes of frog neuromuscular junctions in high calcium solutions. Proc R Soc Lond B Biol Sci 178: 407-15.
  5. Heuser, J. and R. Miledi (1971). Effects of lanthanum ions on function and structure of frog neuromuscular junctions. Proc R Soc Lond B Biol Sci 179: 247-60.
  6. Heuser, J. and A. M. Lennon (1973). Morphological evidence for exocytosis of acetylcholine during formation of synaptosomes from Torpedo electric organ. J Physiol 233: 39P-41P.
  7. Heuser, J. E. and T. S. Reese (1973). Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction. J Cell Biol 57: 315-44.
  8. Jablecki, C. K., J. E. Heuser and S. Kaufman (1973). Autoradiographic localization of new RNA synthesis in hypertrophying skeletal muscle. J Cell Biol 57: 743-59.
  9. Heuser, J. E. (1974). Proceedings: A possible origin of the 'giant' spontaneous potentials that occur after prolonged transmitter release at fr sog neuromuscular junctions. J Physiol 239: 106P-108P.
  10. Heuser, J. E. and T. S. Reese (1974). Morphology of synaptic vesicle discharge and reformation at the frog neuromuscular junction in: M. V. L. Bennett (eds.), Synaptic Transmission and Neuronal Interaction (pp. 59-78). New York: Raven Press.
  11. Heuser, J. E., T. S. Reese and D. M. Landis (1974). Functional changes in frog neuromuscular junctions studied with freeze-fracture. J Neurocytol 3: 109-31.
  12. Heuser, J. E. (1976). Morphology of synaptic vesicle discharge and reformation at the frog neuromuscular junction in: S. Thesleff (eds.), The Motor Innervation of Muscle (pp. 51-115). London: Academic Press.
  13. Heuser, J. E. (1976). Ultrafast freezing to capture the structural changes that underlie neuromuscular transmission in: L. P. Rowland (eds.), Exploratory Concepts in Muscular Dystrophy (pp. 215-239). Amsterdam: Excerpta Medica.
  14. Heuser, J. E., T. S. Reese and D. M. Landis (1976). Preservation of synaptic structure by rapid freezing. Cold Spring Harb Symp Quant Biol 40: 17-24.
  15. Heuser, J. E. (1977). Synaptic vesicle exocytosis revealed in quick-frozen frog neuromuscular junctions treated with 4-ampyrodine and given a single electrical shock. pp. 215-239 in: Society for Neuroscience Symposia, Vol II: Approaches to the Cell Biology of Neurons, eds: W.M.Cowan and J.A.Ferrandelli. Soc.Neurosci, Bethesda, MD.
  16. Heuser, J. E. and R. Llinas (1977). Depolarization-release coupling: report of a neurosciences research program workshop in: (eds.), NRP Bulletin (pp. 603-622).
  17. Heuser, J. E. and T. S. Reese (1977). The structure of the synapse in: Handbook of the Nervous System (pp. 261-294).
  18. Strong, P. N., J. E. Heuser and R. B. Kelly (1977). Selective enzymatic hydrolysis of nerve terminal phospholipids by beta-bungarotoxin: biochemical and morphological studies. Prog Clin Biol Res 15: 227-49.
  19. Franzini-Armstrong, C., J. E. Heuser, T. S. Reese, A. P. Somlyo and A. V. Somlyo (1978). T-tubule swelling in hypertonic solutions: a freeze substitution study. J Physiol 283: 133-40.
  20. Heuser, J. E. (1978). Quick-freezing evidence in favor of the vesicular hypothesis. Trends in Neurosciences: 80-82.
  21. Heuser, J. E. (1978). Synaptic vesicle exocytosis and recycling during transmitter discharge from the neuromuscular junction in: S. C. Silverstein (eds.), Life Science Research Report (pp. 445-464). Berlin: Dahlem Konferenzen.
  22. Basbaum, C. B. and J. E. Heuser (1979). Morphological studies of stimulated adrenergic axon varicosities in the mouse vas deferens. J Cell Biol 80: 310-25.
  23. Chandler, D. E. and J. Heuser (1979). Membrane fusion during secretion: cortical granule exocytosis in sex urchin eggs as studied by quick-freezing and freeze-fracture. J Cell Biol 83: 91-108.
  24. Heuser, J. E. and T. S. Reese (1979). Synaptic vesicle exocytosis captured by quick-freezing in: (eds.), Fourth N.R.P. Intensive Study Program (pp. 573-600). Cambridge: MIT Press.
  25. Heuser, J. E. and T. S. Reese (1979). Changes in structure of the presynaptic membrane during transmitter secretion in: M. Otsuka and Z. Hall (eds.), Neurobiology of Synaptic Transmission (pp. 3-11). Toronto: Wiley & Sons.
  26. Heuser, J. E., T. S. Reese, M. J. Dennis, Y. Jan, L. Jan and L. Evans (1979). Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol 81: 275-300.
  27. Heuser, J. E. and S. R. Salpeter (1979). Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane. J Cell Biol 82: 150-73.
  28. Heuser, J. E. and S. R. Salpeter (1979). Ultrastructure of the cholinergic synapse in: (eds.), The Cholinergic Synapse (pp. 478-480).
  29. Shotton, D. M., J. E. Heuser, B. F. Reese and T. S. Reese (1979). Postsynaptic membrane folds of the frog neuromuscular junction visualized by scanning electron microscopy. Neuroscience 4: 427-35.
  30. Stevens, C. F. (1979). The neuron [micrographs provided by J. Heuser]. Sci Am 241: 54-65.
  31. Chandler, D. E. and J. Heuser (1980). The vitelline layer of the sea urchin egg and its modification during fertilization. A freeze-fracture study using quick-freezing and deep-etching. J Cell Biol 84: 618-32.
  32. Chandler, D. E. and J. E. Heuser (1980). Arrest of membrane fusion events in mast cells by quick-freezing. J Cell Biol 86: 666-74.
  33. Heuser, J. (1980). Three-dimensional visualization of coated vesicle formation in fibroblasts. J Cell Biol 84: 560-83.
  34. Heuser, J. E. (1980). A budding field in cell biology (Review). Cell 22: 634-636.
  35. Heuser, J. E. (1980). 3-D visualization of membrane and cytoplasmic specializations at the frog neuromuscular junction in: Taxi (eds.), INSERM Symposium (pp.: Elsevier/North Holland Biomedical Press.
  36. Heuser, J. E. (1980). Quick-freeze, deep-etch method of preparing samples for 3-D electron microscopy. Trends in Biochemical Sciences 6: 64-68.
  37. Heuser, J. E. and M. W. Kirschner (1980). Filament organization revealed in platinum replicas of freeze-dried cytoskeletons. J Cell Biol 86: 212-34.
  38. Klymkowsky, M. W., J. E. Heuser and R. M. Stroud (1980). Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol 85: 823-38.
  39. Chandler, D. E. and J. Heuser (1981). Postfertilization growth of microvilli in the sea urchin egg: new views from eggs that have been quick-frozen, freeze-fractured, and deeply etched. Dev Biol 82: 393-400.
  40. Friend, D. S. and J. E. Heuser (1981). Orderly particle arrays on the mitochondrial outer membrane in rapidly-frozen sperm. Anat Rec 199: 159-75.
  41. Heuser, J. (1981). Preparing biological samples for stereomicroscopy by the quick-freeze, deep-etch, rotary-replication technique. Methods Cell Biol 22: 97-122.
  42. Heuser, J. E. and T. S. Reese (1981). Structural changes after transmitter release at the frog neuromuscular junction. J Cell Biol 88: 564-80.
  43. Hirokawa, N. and J. E. Heuser (1981). Structural evidence that botulinum toxin blocks neuromuscular transmission by impairing the calcium influx that normally accompanies nerve depolarization. J Cell Biol 88: 160-71.
  44. Hirokawa, N. and J. E. Heuser (1981). Quick-freeze, deep-etch visualization of the cytoskeleton beneath surface differentiations of intestinal epithelial cells. J Cell Biol 91: 399-409.
  45. Aggeler, J. and Z. Werb (1982). Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin. J Cell Biol 94: 613-23. [directed, illustrated, and supported by J.E. Heuser]
  46. Goodenough, U. W. and J. E. Heuser (1982). Substructure of the outer dynein arm. J Cell Biol 95: 798-815.
  47. Hirokawa, N. and J. Heuser (1982). The inside and outside of gap-junction membranes visualized by deep etching. Cell 30: 395-406.
  48. Hirokawa, N. and J. E. Heuser (1982). Internal and external differentiations of the postsynaptic membrane at the neuromuscular junction. J Neurocytol 11: 487-510.
  49. Hirokawa, N. and J. E. Heuser (1982). Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method. J Cell Biol 94: 129-42.
  50. Hirokawa, N., L. G. Tilney, K. Fujiwara and J. E. Heuser (1982). Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cells. J Cell Biol 94: 425-43.
  51. Roof, D. J. and J. E. Heuser (1982). Surfaces of rod photoreceptor disk membranes: integral membrane components. J Cell Biol 95: 487-500.
  52. Roof, D. J., J. I. Korenbrot and J. E. Heuser (1982). Surfaces of rod photoreceptor disk membranes: light-activated enzymes. J Cell Biol 95: 501-9.
  53. Schaeffer, S. F., E. Raviola and J. E. Heuser (1982). Membrane specializations in the outer plexiform layer of the turtle retina. J Comp Neurol 204: 253-67.
  54. Adair, W. S., C. Hwang and U. W. Goodenough (1983). Identification and visualization of the sexual agglutinin from the mating-type plus flagellar membrane of Chlamydomonas. Cell 33: 183-93. [Figures by J.E. Heuser]
  55. Cooper, J. B., W. S. Adair, R. P. Mecham, J. E. Heuser and U. W. Goodenough (1983). Chlamydomonas agglutinin is a hydroxyproline-rich glycoprotein. Proc Natl Acad Sci USA 80: 5898-5901.
  56. Harding, C., J. Heuser and P. Stahl (1983). Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol 97: 329-39.
  57. Harding, C. and P. Stahl (1983). Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing. Biochem Biophys Res Commun 113: 650-8. [directed & supported by J.E. Heuser]
  58. Heuser, J. E. (1983). Structure of the myosin crossbridge lattice in insect flight muscle. J Mol Biol 169: 123-54.
  59. Heuser, J. E. (1983). Procedure for freeze-drying molecules adsorbed to mica flakes. J Mol Biol 169: 155-95.
  60. Heuser, J. E. and R. Cooke (1983). Actin-myosin interactions visualized by the quick-freeze, deep-etch replica technique. J Mol Biol 169: 97-122.
  61. Ip, W. and J. Heuser (1983). Direct visualization of the myosin crossbridge helices on relaxed rabbit psoas thick filaments. J Mol Biol 171: 105-9.
  62. Monk, B. C., W. S. Adair, R. A. Cohen and U. W. Goodenough (1983). Topography of Chlamydomonas: fine structure and polypeptide components of the gametic flagellar membrane surface and the cell wall. Planta 158: 517-533. [Micrographs provided by J. Heuser]
  63. Goodenough, U. and J. Heuser (1984). Structural comparison of purified dynein proteins with in situ dynein arms. J Mol Biol 180: 1083-118.
  64. Goodenough, W., W. S. Adair, P. Colllin-Osdoby and J. E. Heuser (1984). Chlamydomonas cells in contact in: E. Gall and G. Edelman (eds.), Cells In Contact New York: John Wiley.
  65. Harding, C., J. Heuser and P. Stahl (1984). Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. Eur J Cell Biol 35: 256-63.
  66. Ip, W., D. B. Murphy and J. E. Heuser (1984). Arrest of pigment granule motion in erythrophores by quick-freezing. J Ultrastruct Res 86: 162-75.
  67. Miller, T. M. and J. E. Heuser (1984). Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction. J Cell Biol 98: 685-98.
  68. Souto-Padron, T., W. de Souza and J. E. Heuser (1984). Quick-freeze, deep-etch rotary replication of Trypanosoma cruzi and Herpetomonas megaseliae. J Cell Sci 69: 167-78.
  69. Goodenough, U. W., W. S. Adair, P. Collin-Osdoby and J. E. Heuser (1985). Structure of the Chlamydomonas agglutinin and related flagellar surface proteins in vitro and in situ. J Cell Biol 101: 924-41.
  70. Goodenough, U. W., W. S. Adair, P. Collin-Osdoby and J. E. Heuser (1985). Chapter 6: Chlamydomonas Cells in Contact in: G. Edelman and J.-P. Theiry (eds.), The Cell In Contact: Adhesions and Junctions as Morphogenetic Determinants (pp. 111-135). San Diego: Neurosciences Research Foundation, Inc.
  71. Goodenough, U. W. and J. E. Heuser (1985). Substructure of inner dynein arms, radial spokes, and the central pair/projection complex of cilia and flagella. J Cell Biol 100: 2008-18.
  72. Goodenough, U. W. and J. E. Heuser (1985). Outer and inner dynein arms of cilia and flagella. Cell 41: 341-2.
  73. Goodenough, U. W. and J. E. Heuser (1985). The Chlamydomonas cell wall and its constituent glycoproteins analyzed by the quick-freeze, deep-etch technique. J Cell Biol 101: 1550-68.
  74. Heuser, J. and T. Kirchhausen (1985). Deep-etch views of clathrin assemblies. J Ultrastruct Res 92: 1-27.
  75. Ip, W., J. E. Heuser, Y. Y. Pang, M. K. Hartzer and R. M. Robson (1985). Subunit structure of desmin and vimentin protofilaments and how they assemble into intermediate filaments. Ann N Y Acad Sci 455: 185-99.
  76. Sale, W. S., U. W. Goodenough and J. E. Heuser (1985). The substructure of isolated and in situ outer dynein arms of sea urchin sperm flagella. J Cell Biol 101: 1400-12.
  77. Goodenough, U. W., B. Gebhart, R. P. Mecham and J. E. Heuser (1986). Crystals of the Chlamydomonas reinhardtii cell wall: polymerization, depolymerization, and purification of glycoprotein monomers. J Cell Biol 103: 405-17.
  78. Heuser, J. E. (1986). Different structural states of a microtubule cross-linking molecule, captured by quick-freezing motile axostyles in protozoa. J Cell Biol 103: 2209-27.
  79. Kirchhausen, T., S. C. Harrison and J. Heuser (1986). Configuration of clathrin trimers: evidence from electron microscopy. J Ultrastruct Mol Struct Res 94: 199-208.
  80. Adair, W. S., S. A. Steinmetz, D. M. Mattson, U. W. Goodenough and J. E. Heuser (1987). Nucleated assembly of Chlamydomonas and Volvox cell walls. J Cell Biol 105: 2373-82.
  81. Conzelman, K. A. and M. S. Mooseker (1987). The 110-kD protein-calmodulin complex of the intestinal microvillus is an actin-activated MgATPase. J Cell Biol 105: 313-24.
  82. Goodenough, U. W., B. Gebhart, V. Mermall, D. R. Mitchell and J. E. Heuser (1987). High-pressure liquid chromatography fractionation of Chlamydomonas dynein extracts and characterization of inner-arm dynein subunits. J Mol Biol 194: 481-94.
  83. Heuser, J. E. (1987). Crossbridges in insect flight muscles of the blowfly (Sarcophaga bullata). J Muscle Res Cell Motil 8: 303-21.
  84. Heuser, J. E., J. H. Keen, L. M. Amende, R. E. Lippoldt and K. Prasad (1987). Deep-etch visualization of 27S clathrin: a tetrahedral tetramer. J Cell Biol 105: 1999-2009.
  85. Peterson, J. B., J. E. Heuser and D. L. Nelson (1987). Dissociation and reassociation of trichocyst proteins: biochemical and ultrastructural studies. J Cell Sci 87 ( Pt 1): 3-25.
  86. Collier, N. C., J. Heuser, M. A. Levy and M. J. Schlesinger (1988). Ultrastructural and biochemical analysis of the stress granule in chicken embryo fibroblasts. J Cell Biol 106: 1131-9.
  87. Goodenough, U. W. and J. E. Heuser (1988). Molecular reorganization of cell wall crystals from Chlamydomonas reinhardtii and Volvox carteri. Journal of Cell Science 90: 717-733.
  88. Goodenough, U. W. and J. E. Heuser (1988). Molecular organization of the cell wall and cell-wall crystals from Chlamydomonas eugamatos. J Cell Sci 90: 735-750.
  89. Heuser, J. E. and J. Keen (1988). Deep-etch visualization of proteins involved in clathrin assembly. J Cell Biol 107: 877-86.
  90. Solans, C., J. G. Dominguez, J. L. Parra, J. E. Heuser and S. E. Friberg (1988). Gelled emulsions with a high water content. Colloid and Polymer Science 266: 570-574.
  91. Coleman, T. R., D. J. Fishkind, M. S. Mooseker and J. S. Morrow (1989). Functional diversity among spectrin isoforms. Cell Motility & the Cytoskeleton 12: 225-47. [Micrographs provided by J. Heuser]
  92. Friberg, S., Y. Liang, J. E. Heuser and W. Benton (1989). Surfactant association structures in the system water, orbitol, sodium dodecyl sulfate and hexanol. Journal of Colloid and Interface Science 132: 810-818.
  93. Goodenough, U. W. and J. E. Heuser (1989). Structure of the soluble and in situ ciliary dyneins visualized by quick-freeze, deep-etch electron microscopy in: F. Warner (eds.), Cell Movement, Vol 1: Te Dynein ATPases (pp. 121-140). New York: A.R. Liss Inc.
  94. Goodenough, U. W. and J. E. Heuser (1989). Recognition proteins of Chlamydomonas reinhardtii (chlorophyceae) in: A. W. Coleman, L. J. Gooff and J. R. Stein-Taylor (eds.), Algae as Experimental Systems (pp. 171-185). New York: Alan R. Liss Inc.
  95. Heuser, J. (1989). Effects of cytoplasmic acidification on clathrin lattice morphology. J Cell Biol 108: 401-11.
  96. Heuser, J. (1989). Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH. J Cell Biol 108: 855-64.
  97. Heuser, J. (1989). Protocol for 3-D visualization of molecules on mica via the quick-freeze, deep-etch technique. J Electron Microsc Tech 13: 244-63.
  98. Heuser, J. (1989). The role of coated vesicles in recycling of synaptic vesicle membrane. Cell Biology International Reports 13: 1063-76.
  99. Heuser, J. and J. Griffith (1989). Visualization of RecA protein and its complexes with DNA by quick-freeze/deep-etch electron microscopy. J Mol Biol 210: 473-84.
  100. Heuser, J. and C. J. Steer (1989). Trimeric binding of the 70-kD uncoating ATPase to the vertices of clathrin triskelia: a candidate intermediate in the vesicle uncoating reaction. J Cell Biol 109: 1457-66.
  101. Heuser, J. E. (1989). Development of the quick-freeze, deep-etch, rotary-replication technique of sample preparation for 3-D electron microscopy. Prog Clin Biol Res 295: 71-83.
  102. Heuser, J. E. (1989). Mechanisms behind the organization of membranous organelles in cells. Curr Opin Cell Biol 1: 98-102.
  103. Heuser, J. E. (1989). Review of electron microscopic evidence favouring vesicle exocytosis as the structural basis for quantal release during synaptic transmission. Q J Exp Physiol 74: 1051-69.
  104. Heuser, J. E. and R. G. Anderson (1989). Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol 108: 389-400.
  105. Hollenbeck, P. (1989). Cell motility. Dissecting a molecular motor [micrographs provided by J. Heuser]. Nature 338: 294-5.
  106. Kim, J. I., J. Heuser and M. M. Cox (1989). Enhanced recA protein binding to Z DNA represents a kinetic perturbation of a general duplex DNA binding pathway. J Biol Chem 264: 21848-56.
  107. Mooseker, M. S., K. A. Conzelman, T. R. Coleman, J. E. Heuser and M. P. Sheetz (1989). Characterization of intestinal microvillar membrane disks: detergent-resistant membrane sheets enriched in associated brush border myosin I (110K-calmodulin). J Cell Biol 109: 1153-61.
  108. Scholey, J. M., J. Heuser, J. T. Yang and L. S. Goldstein (1989). Identification of globular mechanochemical heads of kinesin. Nature 338: 355-7.
  109. Mecham, R. P. and J. Heuser (1990). Three-dimensional organization of extracellular matrix in elastic cartilage as viewed by quick freeze, deep etch electron microscopy. Connect Tissue Res 24: 83-93.
  110. Kedersha, N. L., J. E. Heuser, D. C. Chugani and L. H. Rome (1991). Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. J Cell Biol 112: 225-35.
  111. Mecham, R. P. and J. E. Heuser (1991). The Elastic Fiber in: E. Hay (eds.), Cell Biology of the Extracellular Matrix (pp. New York: Plenum Press.
  112. Sampson, L. L., J. Heuser and E. J. Brown (1991). Cytokine regulation of complement receptor-mediated ingestion by mouse peritoneal macrophages. M-CSF and IL-4 activate phagocytosis by a common mechanism requiring autostimulation by IFN-beta. J Immunol 146: 1005-13.
  113. Steer, C. J. and J. E. Heuser (1991). Clathrin and coated vesicles: critical determinants of intracellular trafficking in: C. J. Steer and J. A. Hanover (eds.), Intracellular Trafficking of Proteins (pp. 47-102). Cambridge: Cambridge University Press.
  114. Van Etten, J. L., L. C. Lane and R. H. Meints (1991). Viruses and viruslike particles of eukaryotic algae. Microbiological Reviews 55: 586-620. [All micrographs provided by J.E. Heuser]
  115. Baumrind, N. L., D. Parkinson, D. B. Wayne, J. E. Heuser and A. L. Pearlman (1992). EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn 194: 311-25.
  116. Castellino, F., J. Heuser, S. Marchetti, B. Bruno and A. Luini (1992). Glucocorticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotropin release. Proc Natl Acad Sci U S A 89: 3775-9.
  117. Goldberg, A. L. and K. L. Rock (1992). Proteolysis, proteasomes and antigen presentation [micrographs provided by J. Heuser]. Nature 357: 375-9.
  118. Kuehn, M. J., J. Heuser, S. Normark and S. J. Hultgren (1992). P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. Nature 356: 252-5.
  119. Nathke, I. S., J. Heuser, A. Lupas, J. Stock, C. W. Turck and F. M. Brodsky (1992). Folding and trimerization of clathrin subunits at the triskelion hub. Cell 68: 899-910.
  120. Robinson, L. J., S. Pang, D. S. Harris, J. Heuser and D. E. James (1992). Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices. J Cell Biol 117: 1181-96.
  121. Rothberg, K. G., J. E. Heuser, W. C. Donzell, Y. S. Ying, J. R. Glenney and R. G. Anderson (1992). Caveolin, a protein component of caveolae membrane coats. Cell 68: 673-82.
  122. Tardieux, I., P. Webster, J. Ravesloot, W. Boron, J. A. Lunn, J. E. Heuser and N. W. Andrews (1992). Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. Cell 71: 1117-30.
  123. Westervelt, P., T. Henkel, D. B. Trowbridge, J. Orenstein, J. Heuser, H. E. Gendelman and L. Ratner (1992). Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants. J Virol 66: 3925-31.
  124. Cheney, R. E., M. K. O'Shea, J. E. Heuser, M. V. Coelho, J. S. Wolenski, E. M. Espreafico, P. Forscher, R. E. Larson and M. S. Mooseker (1993). Brain myosin-V is a two-headed unconventional myosin with motor activity. Cell 75: 13-23.
  125. Heuser, J., Q. Zhu and M. Clarke (1993). Proton pumps populate the contractile vacuoles of Dictyostelium amoebae. J Cell Biol 121: 1311-27.
  126. Jacob-Dubuisson, F., J. Heuser, K. Dodson, S. Normark and S. Hultgren (1993). Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins. Embo J 12: 837-47.
  127. Weidman, P., R. Roth and J. Heuser (1993). Golgi membrane dynamics imaged by freeze-etch electron microscopy: views of different membrane coatings involved in tubulation versus vesiculation. Cell 75: 123-33.
  128. Cooper, J. B., J. E. Heuser and J. E. Varner (1994). 3,4-Dehydroproline inhibits cell wall assembly and cell division in tobacco protoplasts. Plant Physiol 104: 747-52.
  129. Crouch, E., D. Chang, K. Rust, A. Persson and J. Heuser (1994). Recombinant pulmonary surfactant protein D. Post-translational modification and molecular assembly. J Biol Chem 269: 15808-13.
  130. Crouch, E., A. Persson, D. Chang and J. Heuser (1994). Molecular structure of pulmonary surfactant protein D (SP-D). J Biol Chem 269: 17311-9.
  131. Prasad, K., J. Heuser, E. Eisenberg and L. Greene (1994). Complex formation between clathrin and uncoating ATPase. Journal of Biological Chemistry 269: 6931-9.
  132. Schafer, D. A., S. R. Gill, J. A. Cooper, J. E. Heuser and T. A. Schroer (1994). Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. J Cell Biol 126: 403-12.
  133. Shyng, S. L., J. E. Heuser and D. A. Harris (1994). A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. J Cell Biol 125: 1239-50.
  134. Sibley, L. D., J. Dobrowolsky, H. Morisaki and J. E. Heuser (1994). Invasion and intracellular survival by Toxoplasma gondii in: D. G. Russell (eds.), Clin. Infect. Dis., Vol. 1: Strategies for Intracelular Survival of Microbes (pp. 245-264). London: Ballier Tindall Pub.
  135. Sturgill-Koszycki, S., P. H. Schlesinger, P. Chakraborty, P. L. Haddix, H. L. Collins, A. K. Fok, R. D. Allen, S. L. Gluck, J. Heuser and D. G. Russell (1994). Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263: 678-81.
  136. Burns, C. G., M. Reedy, J. Heuser and A. De Lozanne (1995). Expression of light meromyosin in Dictyostelium blocks normal myosin II function. J Cell Biol 130: 605-12.
  137. Jones, C. H., J. S. Pinkner, R. Roth, J. Heuser, A. V. Nicholes, S. N. Abraham and S. J. Hultgren (1995). FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. Proc Natl Acad Sci U S A 92: 2081-5.
  138. Morisaki, J. H., J. E. Heuser and L. D. Sibley (1995). Invasion of Toxoplasma gondii occurs by active penetration of the host cell. J Cell Sci 108 ( Pt 6): 2457-64.
  139. Sapperstein, S. K., D. M. Walter, A. R. Grosvenor, J. E. Heuser and M. G. Waters (1995). p115 is a general vesicular transport factor related to the yeast endoplasmic reticulum to Golgi transport factor Uso1p. Proc Natl Acad Sci U S A 92: 522-6.
  140. Hartshorn, K., D. Chang, K. Rust, M. White, J. Heuser and E. Crouch (1996). Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A. Am J Physiol 271: L753-62.
  141. Lupetti, P., J. E. Heuser, R. Manetti, P. Massari, S. Lanzavecchia, P. L. Bellon, R. Dallai, R. Rappuoli and J. L. Telford (1996). Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J Cell Biol 133: 801-7.
  142. Rooney, I. A., J. E. Heuser and J. P. Atkinson (1996). GPI-anchored complement regulatory proteins in seminal plasma. An analysis of their physical condition and the mechanisms of their binding to exogenous cells. J Clin Invest 97: 1675-86.
  143. St Geme, J. W., J. S. Pinkner, 3rd, G. P. Krasan, J. Heuser, E. Bullitt, A. L. Smith and S. J. Hultgren (1996). Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. Proc Natl Acad Sci U S A 93: 11913-8.
  144. Clarke, M. and J. Heuser (1997). Water and ion transport in: Y. Maeda, K. Inouye and I. Takeuchi (eds.), Dictyostelium: A Model System for Cell and Developmental Biology (pp. Tokyo: University Academic Press.
  145. Cover, T. L., P. I. Hanson and J. E. Heuser (1997). Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J Cell Biol 138: 759-69.
  146. Gee, M. A., J. E. Heuser and R. B. Vallee (1997). An extended microtubule-binding structure within the dynein motor domain. Nature 390: 636-9.
  147. Hanson, P. I., J. E. Heuser and R. Jahn (1997). Neurotransmitter release - four years of SNARE complexes. Curr Opin Neurobiol 7: 310-5.
  148. Hanson, P. I., R. Roth, H. Morisaki, R. Jahn and J. E. Heuser (1997). Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell 90: 523-35.
  149. Lupetti, P., J. E. Heuser, M. Vegni Talluri and R. Dallai (1997). The gliding movement of gregarines: a high resolution ultrastructural stud in: A. Delfino (eds.), Recent Advances in Microscopy of Cells, Tissues, and Organs (pp. Rome.
  150. Hartman, J. J., J. Mahr, K. McNally, K. Okawa, A. Iwamatsu, S. Thomas, S. Cheesman, J. Heuser, R. D. Vale and F. J. McNally (1998). Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93: 277-87.
  151. Hsu, S. C., C. D. Hazuka, R. Roth, D. L. Foletti, J. Heuser and R. H. Scheller (1998). Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron 20: 1111-22.
  152. Katz, L., P. I. Hanson, J. E. Heuser and P. Brennwald (1998). Genetic and morphological analyses reveal a critical interaction between the C-termini of two SNARE proteins and a parallel four helical arrangement for the exocytic SNARE complex. Embo J 17: 6200-9.
  153. Lupetti, P., C. Mencarelli, M. Rosetto, J. E. Heuser and R. Dallai (1998). Structural and molecular characterization of dynein in a gall-midge insect having motile sperm with only the outer arm. Cell Motil Cytoskeleton 39: 303-17.
  154. Mullins, R. D., J. A. Heuser and T. D. Pollard (1998). The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A 95: 6181-6.
  155. Mulvey, M. A., Y. S. Lopez-Boado, C. L. Wilson, R. Roth, W. C. Parks, J. Heuser and S. J. Hultgren (1998). Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 282: 1494-7.
  156. Smith, T. L. (1998). Picture story. A forceful 'windshield wiper'? Nature Structural Biology 5: 14. [Micrographs provided by J. Heuser].
  157. Soto, G. E., K. W. Dodson, D. Ogg, C. Liu, J. Heuser, S. Knight, J. Kihlberg, C. H. Jones and S. J. Hultgren (1998). Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus. Embo J 17: 6155-67.
  158. Thanassi, D. G., E. T. Saulino, M. J. Lombardo, R. Roth, J. Heuser and S. J. Hultgren (1998). The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane. Proc Natl Acad Sci U S A 95: 3146-51.
  159. Eckley, D. M., S. R. Gill, K. A. Melkonian, J. B. Bingham, H. V. Goodson, J. E. Heuser and T. A. Schroer (1999). Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. J Cell Biol 147: 307-20.
  160. Graves, M. V., D. E. Burbank, R. Roth, J. Heuser, P. L. DeAngelis and J. L. Van Etten (1999). Hyaluronan synthesis in virus PBCV-1-infected chlorella-like green algae. Virology 257: 15-23.
  161. Hakansson, S., H. Morisaki, J. Heuser and L. D. Sibley (1999). Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion. Mol Biol Cell 10: 3539-47.
  162. Beatty, W. L., E. R. Rhoades, H. J. Ullrich, D. Chatterjee, J. E. Heuser and D. G. Russell (2000). Trafficking and release of mycobacterial lipids from infected macrophages. Traffic 1: 235-47.
  163. Arpinati, M., C. L. Green, S. Heimfeld, J. E. Heuser and C. Anasetti (2000). Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 95: 2484-2490.
  164. Fujimoto, L. M., R. Roth, J. E. Heuser and S. L. Schmid (2000). Actin assembly plays a variable, but not obligatory role in receptor-mediated endocytosis in mammalian cells. Traffic 1: 161-71.
  165. Happe, S., M. Cairns, R. Roth, J. Heuser and P. Weidman (2000). Coatomer vesicles are not required for inhibition of Golgi transport by G-protein activators. Traffic 1: 342-53.
  166. Heuser, J. (2000). The production of 'cell cortices' for light and electron microscopy. Traffic 1: 545-52.
  167. Heuser, J. (2000). How to convert a traditional electron microscopy laboratory to digital imaging: follow the 'middle road'. Traffic 1: 614-21.
  168. Heuser, J. E. (2000). Membrane traffic in anaglyph stereo. Traffic 1: 35-7.
  169. Moritz, M., M. B. Braunfeld, V. Guenebaut, J. Heuser and D. A. Agard (2000). Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. Nat Cell Biol 2: 365-70.
  170. Mulvey, M. A., J. D. Schilling, J. J. Martinez and S. J. Hultgren (2000). Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proceedings of the National Academy of Sciences of the United States of America 97: 8829-35. [all micrographs provided by J. Heuser]
  171. Saber-Lichtenberg, Y., K. Brix, A. Schmitz, J. E. Heuser, J. H. Wilson, L. Lorand and V. Herzog (2000). Covalent cross-linking of secreted bovine thyroglobulin by transglutaminase. Faseb J 14: 1005-14.
  172. DeMattos, R. B., R. P. Brendza, J. E. Heuser, M. Kierson, J. R. Cirrito, J. Fryer, P. M. Sullivan, A. M. Fagan, X. Han and D. M. Holtzman (2001). Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. Neurochem Int 39: 415-25.
  173. Engqvist-Goldstein, A. E., R. A. Warren, M. M. Kessels, J. H. Keen, J. Heuser and D. G. Drubin (2001). The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro. J Cell Biol 154: 1209-23.
  174. Figueroa-Arredondo, P., J. E. Heuser, N. S. Akopyants, J. H. Morisaki, S. Giono-Cerezo, F. Enriquez-Rincon and D. E. Berg (2001). Cell vacuolation caused by Vibrio cholerae hemolysin. Infect Immun 69: 1613-24.
  175. Heuser, J. E. and J. G. Donaldson (2001). Membrane-cytoskeletal dynamics in a new dimension. Nat Cell Biol 3: E140-2.
  176. Matsuoka, K., R. Schekman, L. Orci and J. E. Heuser (2001). Surface structure of the COPII-coated vesicle. Proc Natl Acad Sci U S A 98: 13705-9.
  177. Mencarelli, C., P. Lupetti, M. Rosetto, D. Mercati, J. E. Heuser and R. Dallai (2001). Molecular structure of dynein and motility of a giant sperm axoneme provided with only the outer dynein arm. Cell Motil Cytoskeleton 50: 129-46.
  178. Raibaud, A., P. Lupetti, R. E. Paul, D. Mercati, P. T. Brey, R. E. Sinden, J. E. Heuser and R. Dallai (2001). Cryofracture electron microscopy of the ookinete pellicle of Plasmodium gallinaceum reveals the existence of novel pores in the alveolar membranes. J Struct Biol 135: 47-57.
  179. Volkmann, N., K. J. Amann, S. Stoilova-McPhie, C. Egile, D. C. Winter, L. Hazelwood, J. E. Heuser, R. Li, T. D. Pollard and D. Hanein (2001). Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Science 293: 2456-9.
  180. Heuser, J. E. (2001). A critical comparison between the two current methods of viewing frozen, live cells in the electron microscope: cryo-electron microscopic tomography versus "deep-etch" electron microscopy. Biomedical Reviews 12: 11-29.
  181. Acehan, D., X. Jiang, D. G. Morgan, J. E. Heuser, X. Wang and C. W. Akey (2002). Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell 9: 423-32.
  182. Adrian, M., T. L. Cover, J. Dubochet and J. E. Heuser (2002). Multiple oligomeric states of the Helicobacter pylori vacuolating toxin demonstrated by cryo-electron microscopy. J Mol Biol 318: 121-33.
  183. Chapman, M. R., L. S. Robinson, J. S. Pinkner, R. Roth, J. Heuser, M. Hammar, S. Normark and S. J. Hultgren (2002). Role of Escherichia coli curli operons in directing amyloid fiber formation. Science 295: 851-5.
  184. Clarke, M., J. Kohler, Q. Arana, T. Liu, J. Heuser and G. Gerisch (2002). Dynamics of the vacuolar H(+)-ATPase in the contractile vacuole complex and the endosomal pathway of Dictyostelium cells. J Cell Sci 115: 2893-905.
  185. Clarke, M., J. Kohler, J. Heuser and G. Gerisch (2002). Endosome fusion and microtubule-based dynamics in the early endocytic pathway of dictyostelium. Traffic 3: 791-800.
  186. Davis, E. C., R. A. Roth, J. E. Heuser and R. P. Mecham (2002). Ultrastructural properties of ciliary zonule microfibrils. J Struct Biol 139: 65-75.
  187. Liu, T., C. Mirschberger, L. Chooback, Q. Arana, Z. Dal Sacco, H. MacWilliams and M. Clarke (2002). Altered expression of the 100 kDa subunit of the Dictyostelium vacuolar proton pump impairs enzyme assembly, endocytic function and cytosolic pH regulation. J Cell Sci 115: 1907-18. [with assistance from J. E. Heuser]
  188. Ungar, D., T. Oka, E. E. Brittle, E. Vasile, V. V. Lupashin, J. E. Chatterton, J. E. Heuser, M. Krieger and M. G. Waters (2002). Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J Cell Biol 157: 405-15.
  189. Weaver, A. M., J. E. Heuser, A. V. Karginov, W. L. Lee, J. T. Parsons and J. A. Cooper (2002). Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol 12: 1270-8.
  190. Gerisch, G., J. Heuser and M. Clarke (2002). Tubular-vesicular transformation in the contractile vacuole system of Dictyostelium. Cell Biol Int 26: 845-52.
  191. Fields, S. D., Q. Arana, J. Heuser and M. Clarke (2002). Mitochondrial membrane dynamics are altered in cluA- mutants of Dictyostelium. Journal of Musc Res and Cell Motil 23: 829-38.
  192. Heuser, J. (2003). Whatever happened to the 'microtrabecular concept'? Biol Cell 94: 561-96.
  193. Cao, H., J. D. Orth, J. Chen, S. G. Weller, J. E. Heuser and M. A. McNiven (2003). Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol 23: 2162-70.
  194. Anderson, G. G., J. J. Palermo, J. D. Schilling, R. Roth, J. Heuser and S. J. Hultgren (2003). Intracellular bacterial biofilm-like pods in urinary tract infections. Science 301: 105-7.
  195. Heuser, J. (2003). Pollard/Earnshaw cell biology. Tissue Cell 35: 153-154.
  196. Heuser, J. (2003). Retrospective. "My little spontaneous blips". Science 300: 1248.
  197. Ritty, T. M., R. Roth and J. E. Heuser (2003). Tendon cell array isolation reveals a previously unknown fibrillin-2-containing macromolecular assembly. Structure 11: 1179-1188.
  198. Tsao, T. S., E. Tomas, H. E. Murrey, C. Hug, D. H. Lee, N. B. Ruderman, J. E. Heuser and H. F. Lodish (2003). Role of disulfide bonds in Acrp30/Adiponectin structure and signaling specificity: Different oligomers activate different signal transduction pathways. J Biol Chem. 278: 50810-50817.
  199. Zeng, Y., N. Tao, K. N. Chung, J. E. Heuser and D. M. Lublin (2003). Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1. J Biol Chem 278: 45931-45936.
  200. Moskowitz, H. S., J. Heuser, T. E. McGraw and T. A. Ryan (2003). Targeted chemical disruption of clathrin function in living cells. Mol Biol Cell 14: 4437-4447.
  201. Stamm, L. M., J. H. Morisaki, L. Y. Gao, R. L. Jeng, K. L. Mcdonald, R. Roth, S. Takeshita, J. Heuser, M. D. Welch and E. J. Brown. 2003. Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med. 198: 1361-1368.
  202. Balcer, H. I., A. L. Goodman, A. A. Rodal, E. Smith, J. Kugler, J. E. Heuser and B. L. Goode. 2003. Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1. Curr Biol. 13: 2159-2169.
  203. Bretschneider, T., S. Diez, K. Anderson, J. Heuser, M. Clarke, A. Muller-Taubenberger, J. Kohler and G. Gerisch (2004). Dynamic actin patterns and arp2/3 assembly at the substrate-attached surface of motile cells. Curr Biol 14: 1-10.
  204. Mishra, S. K., M. J. Hawryluk, T. J. Brett, P. A. Keyel, A. L. Dupin, A. Jha, J. E. Heuser, D. H. Fremont and L. M. Traub (2004). Dual-engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. J Biol Chem. 279L 46191-46203.
  205. Naismith, T. V., J. E. Heuser, X. O. Breakefield and P. I. Hanson (2004). TorsinA in the nuclear envelope. Proc Natl Acad Sci U S A 101: 7612-7617.
  206. Sexton, J. A., J. S. Pinkner, R. Roth, J. E. Heuser, S. J. Hultgren and J. P. Vogel (2004). The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol 186: 1658-1666.
  207. Engqvist-Goldstein, A. E., C. X. Zhang, S. Carreno, C. Barroso, J. E. Heuser and D. G. Drubin (2004). RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol Biol Cell 15: 1666-1679.
  208. Mishra, S. K., M. J. Hawryluk, T. J. Brett, P. A. Keyel, A. L. Dupin, A. Jha, J. E. Heuser, D. H. Fremont and L. M. Traub. 2004. Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. J Biol Chem. 279: 46191-46203.
  209. Mccarren, J., J. Heuser, R. Roth, N. Yamada, M. Martone and B. Brahamsha. 2005. Inactivation of swmA results in the loss of an outer cell layer in a swimming synechococcus strain. J Bacteriol. 187: 224-230.
  210. Quinlan, M. E., J. E. Heuser, E. Kerkhoff and R. D. Mullins. 2005. Drosophila Spire is an actin nucleation factor. Nature. 433: 382-388.
  211. Heuser, J. Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic "honeycomb" surface coat. J Cell Biol. 169: 269-283.
  212. Szajner, P., A. S. Weisberg, J. Lebowitz, J. Heuser and B. Moss (2005). External scaffold of spherical immature poxvirus particles is made of protein trimers, forming a honeycomb lattice. J Cell Biol 170: 971-981.
  213. Sahoo, N., W. Beatty, J. Heuser, D. Sept and L. D. Sibley (2005). Unusual Kinetic and Structural Properties Control Rapid Assembly and Turnover of Actin in the Parasite Toxoplasma gondii. Mol Biol Cell. [epub ahead of print]
  214. Gill, D. B., D. Spitzer, M. Koomey, J. E. Heuser and J. P. Atkinson (2005). Release of host-derived membrane vesicles following pilus-mediated adhesion of Neisseria gonorrhoeae. Cell Microbiol 7: 1672-1683.
  215. Keyel, P. A., S. K. Mishra, R. Roth, J. E. Heuser, S. C. Watkins and L. M. Traub (2006). A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell 17: 4300-17.
  216. Heuser, J. (2006). Evidence for recycling of contractile vacuole membrane during osmoregulation in Dictyostelium amoebae--a tribute to Gunther Gerisch. Eur J Cell Biol 85: 859-71.
  217. Liberton, M., R. Howard Berg, J. Heuser, R. Roth and H. B. Pakrasi (2006). Ultrastructure of the membrane systems in the unicellular cyanobacterium Synechocystis sp. strain PCC 6803. Protoplasma 227: 129-38.
  218. Buscher, A. Z., S. Grass, J. Heuser, R. Roth and J. W. St Geme, 3rd (2006). Surface anchoring of a bacterial adhesin secreted by the two-partner secretion pathway. Mol Microbiol 61: 470-83.
  219. Edeling, M. A., S. K. Mishra, P. A. Keyel, A. L. Steinhauser, B. M. Collins, R. Roth, J. E. Heuser, D. J. Owen and L. M. Traub (2006). Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. Dev Cell 10: 329-42.
  220. Hawryluk, M. J., P. A. Keyel, S. K. Mishra, S. C. Watkins, J. E. Heuser and L. M. Traub (2006). Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic 7: 262-81.
  221. Lapaque, N., F. Forquet, C. de Chastellier, Z. Mishal, G. Jolly, E. Moreno, I. Moriyon, J. E. Heuser, H. T. He and J. P. Gorvel (2006). Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts. Cell Microbiol 8: 197-206.
  222. Sahoo, N., W. Beatty, J. Heuser, D. Sept and L. D. Sibley (2006). Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii. Mol Biol Cell 17: 895-906.
  223. Keyel, P. A., S. K. Mishra, R. Roth, J. E. Heuser, S. C. Watkins and L. M. Traub (2006). A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell 17: 4300-17.
  224. Takamori, S., M. Holt, K. Stenius, E. A. Lemke, M. Gronborg, D. Riedel, H. Urlaub, S. Schenck, B. Brugger, P. Ringler, S. A. Muller, B. Rammner, F. Grater, J. S. Hub, B. L. De Groot, G. Mieskes, Y. Moriyama, J. Klingauf, H. Grubmuller, J. Heuser, F. Wieland and R. Jahn (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46.
  225. Cardone, G., D. C. Winkler, B. L. Trus, N. Cheng, J. E. Heuser, W. W. Newcomb, J. C. Brown and A. C. Steven (2007). Visualization of the herpes simplex virus portal in situ by cryo-electron tomography. Virology 361: 426-34.
  226. Orlova, A., E. C. Garner, V. E. Galkin, J. Heuser, R. D. Mullins and E. H. Egelman (2007). The structure of bacterial ParM filaments. Nat Struct Mol Biol 14: 921-6.
  227. Huang, R. H., Y. Wang, R. Roth, X. Yu, A. R. Purvis, J. E. Heuser, E. H. Egelman and J. E. Sadler (2008). Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A 105: 482-7.
  228. Hanson, P. I., R. Roth, Y. Lin and J. E. Heuser (2008). Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol 180: 389-402.
  229. Kim, Y., J. E. Heuser, C. M. Waterman and D. W. Cleveland (2008). CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol 181: 411-9.
  230. Galkin, V. E., X. Yu, J. Bielnicki, J. Heuser, C. P. Ewing, P. Guerry and E. H. Egelman (2008). Divergence of quaternary structures among bacterial flagellar filaments. Science 320: 382-385.
  231. Soman, N. R., G. M. Lanza, J. M. Heuser, P. H. Schlesinger and S. A. Wickline (2008). Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides. Nano Lett 8: 1131-1136.
  232. Sheridan, S. D., X. Yu, R. Roth, J. E. Heuser, M. G. Sehorn, P. Sung, E. H. Egelman and D. K. Bishop (2008). A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. Nucleic Acids Res 36: 4057-4066.
  233. Heuser, J., J. Moller, W. Spendel and G. Pacey (2008). Aqueous foam drainage characterized by terahertz spectroscopy. Langmuir 24: 11414-11421.
  234. Keyel, P. A., J. R. Thieman, R. Roth, E. Erkan, E. T. Everett, S. C. Watkins, J. E. Heuser and L. M. Traub (2008). The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. Mol Biol Cell 19: 5309-5326.
  235. White, M., P. Kingma, T. Tecle, N. Kacak, B. Linders, J. Heuser, E. Crouch and K. Hartshorn (2008). Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus. J Immunol 181: 7936-7943.
  236. Huang, J., R. Roth, J. E. Heuser and J. E. Sadler (2009). Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. Blood 113: 1589-1597.
  237. Ren, P. H., J. E. Lauckner, I. Kachirskaia, J. E. Heuser, R. Melki and R. R. Kopito (2009). Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 11: 219-225.
  238. Pei-Hsien Ren, Ioulia Kachirskaia, John Heuser, and Ron Kopito (2008). Cytoplasmic penetration and prion-like propagation of extracellular polyglutamine aggregates in mammalian cells. Nature Cell Biol. (in press).